The Fremont culture of Utah (c.400–1300 CE) shows a pattern of violent abandonment similar to that documented in the Southwest. Multiple sites show burned structures and skeletal trauma. Janetski's and Madsen's analyses of Fremont skeletal populations document elevated violence rates. The sudden disappearance of Fremont culture c.1300 has been attributed in part to conflict with expanding Ancestral Puebloan and incoming Numic-speaking groups.
Indigenous peoples had inhabited North America for at least 15,000 years before European contact, developing complex societies across every region of the continent. The Mississippian culture, centered on the city of Cahokia near present-day St. Louis, reached its peak around 1100 AD with a population estimated at 10,000 to 20,000 — larger than contemporary London. The Ancestral Puebloans built multi-story stone complexes at Chaco Canyon and Mesa Verde between the 9th and 13th centuries. The Iroquois Confederacy, formed between roughly 1450 and 1600, united five nations under a constitution that influenced later American democratic thinking. Across the eastern woodlands, the Great Plains, the Pacific Coast, and the Southwest, hundreds of distinct nations maintained sophisticated trade networks, agricultural systems, and governance structures. European contact beginning in the late 15th century introduced epidemic disease — smallpox, measles, influenza — which devastated Indigenous populations by an estimated 50 to 90 percent within a century.
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